![]() Usually physical therapy isĪdministered initially for 6 weeks along with an NSAID medication. Only be enrolled if they fail conservative treatment. Swelling, and trouble with activities for at least 4 to 6 weeks. Treatment failure is indicated by Subjects having symptoms of knee pain, Medicine, cortizone injections, or hyaluronic acid injections.ġ. The time frame prior to screening when failure ofĬonservative treatment would have occurred will be one year of symptoms and failure ofĬonservative treatment which includes physical therapy, nonsteroidal anti-inflammatory Enroll subjects who have demonstrated failure or are Have had the benefit of standard of care treatment at less than 3 months before Injection therapy) before receiving experimental therapy. Modification, weight loss, physical therapy, anti-inflammatory medications, or Subjects who have had the benefit of standard of care (SOC) treatment (activity The subjects will also be gettingĪ baseline MRI that will help delineate any further ligament injuries that mayġ0. bucket handle) (A positive McMurrays test onĬlinical exam indicates a significant meniscal tear. ![]() Next Generation Regenerative Medicine (NGRM) will treat subjects withĭegenerative meniscal changes in tears but no acute or large bucket handle tears.)ĩ. Ligamentous sprains [LCL, MCL, Anterior Cruciate Ligament (ACL), Posterior Cruciate Review of the MRI, NGRM will only treat subjects with no grade 2 or grade 3 (A significant LCL and MCL laxity or tear would be determined onĬlinical exam if there is no endpoint on valgus or Varus stress physical exam. No significant Medial Collateral Ligament (MCL) or Lateral Collateral Ligament (LCL) Single symptomatic knee will be enrolled.Ĩ. Least one compartment of the knee either or both knees. X-rays that demonstrate OA with the Kellgren-Lawrence grading scale of 2, 3 or 4 in at Individuals 18 to 80 years old that have knee Osteoarthritis.ħ. With a BMI >40 and 60 and 90 and 60 and 60 ml/min. Body weight > 45 kg and Body Mass Index (BMI) between 18 and 40 kg/m2 (i.e., subjects Healthy, non-smoking, males and females.Ĥ. The subject must be willing and able to provide written informed consent.Ģ.
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